Scientists are developing a cutting-edge vaccine that could stopClostridioides difficilea bacteria known for causing severe gut infectionsin its tracks.

Scientists detailed their development of an experimental vaccine candidate forC.

difficilebacteria, better known as C. diff, in new research this week.

A 3D illustration of C. diff bacteria.

A 3D illustration of C. diff bacteria.© Jennifer Oosthuizen/Science Photo Library via Getty

While many people carryC.

These bacteria can shapeshift and use a variety of tricks to ensure their survival.

So far, their plan looks like it’s working as hoped, at least in mice.

ealth and Human Services Secretary Robert F. Kennedy Jr. speaks at a news conference at the Health and Human Services Department on April 22, 2025 in Washington, DC.

The teams findings werepublishedthis month in the journalScience.

Our approach was to create a multivalent mRNA vaccine that would attack multiple aspects ofC.

But a C. diff vaccine, if successfully developed, would have a tremendous health impact.

Measles Rash

Annually, its thoughtaround 30,000 peopledie from C. diff every year.

Recent research shows that C. diff is becoming more of a problemoutside of hospitals, too.

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