The UNCCH scientists believe theyve narrowed down how this all works.

For the first few days, the floors of both chambers were pleasantly warm.

Finally, on the last day, the floors of both chambers were made painfully hot.

Brain imaging shows activity in the anterior cingulate cortex, a pain-processing region shown above in yellow, when a patient responds to a placebo for pain relief, but the true mechanism for the process remains unknown. New research on mice pinpoints a neural circuit that’s helping to explain how placebos help to reduce pain.

Brain imaging shows activity in the anterior cingulate cortex, a pain-processing region shown above in yellow, when a patient responds to a placebo for pain relief, but the true mechanism for the process remains unknown. New research on mice pinpoints a neural circuit that’s helping to explain how placebos help to reduce pain.© Geoff B Hall

But as the mice ran to chamber two, the neurons connecting these two areas lit up.

But they expressed hope that their work could lead to newer drugs and behavioral therapies for pain relief.

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