And yet, we cant stay away from it.

Astronauts on board the ISS help scientists learn about theeffects spaceflight has on the human body.

Spoiler alert: theyre not great.

How long can the human body endure the harsh space environment?

How long can the human body endure the harsh space environment?NASA

A human mission to Mars would take roughly three years, according toNASA.

But what would that kind of journeyand even longer durations in spacedo to the human body?

How long could a person endure life during a deep-space voyage?

A high-resolution snapshot of the Sun from Solar Orbiter.

And in the worst-case scenario, what would happen if someone were stranded indefinitely on the ISS?

Heres what they had to say.

The simple answer: it depends.

A Webb image of Uranus, its rings, and 9 of its 27 moons.

How long can this be extended?

In this case, people could survive in space for quite a long time.

Without countermeasures such as exercise, their time would be leisurely and enjoyable.

Curiosity Rover

Their only goal would be to enjoy the experience, which could be quite pleasant.

If outside the relative safety of low-Earth orbit, deep-space radiation might have substantial effects.

Some of these effects would be cumulative: an increasing risk of cancer with increasing time in space.

Lucy Donaldjohanson

In parallel with these issues is the little-understood impact of weightlessness on the distribution of fluids in the body.

These might be harbingers of actual neural damage from extended time in space.

If others onboard are available to assist, these people might survive for a long time.

Astronaut Don Pettit

But to what end?

These are among the major risks of which we are aware.

There will likely be others that arise as people spend longer times in space.

NASA’s Lucy spacecraft’s first views of the asteroid Donaldjohanson. The asteroid is outlined with a square in the right image to guide the eye.

This is a challenge.

If they go with work to be done and the intention of returning to Earth, the answer changes.

Even with the current best exercise and nutrition countermeasures, radiation and isolation will take their toll.

Predator Badlands

With little supporting evidence, I would place this limit at about four years.

With artificial gravity it may be much longer.

In this case the limitations may be predominantly due to psychology and radiation.

Jblflip6

The surface of Mars is about one-third of deep space due to Mars body and atmosphere.

So one way to answer is to ask how much risk a person is willing to accept?

If unlimited risk is acceptable then the answer has to do with probabilities of occurrence of the various diseases.

Eufysolocam

Radiation causes DNA damage and creates radicals due to ionizations in tissue leading to increased oxidative stress.

These are precursor changes to various health diseases.

Late effects take some time to appear dependent on which bang out.

Alicia Witt in Urban Legend

This shows that a person can remain in space for over 1.2 years.

Could someone stay longer?

However, the health risks become increasingly severe.

Hp14

Lets consider a 1,000-day mission to Mars, which would be the expected duration with our current technology.

In microgravity, muscles and bones weaken due to the lack of regular weight-bearing activity.

Even more concerning is the radiation exposure.

U.S. President Donald Trump speaks to the media during a guided tour of the John F. Kennedy Center for the Performing Arts before leading a board meeting on March 17, 2025 in Washington, DC.

Vision problems because of fluid shifts in microgravity may persist even after returning to Earth.

The altered immune system response during long-duration missions also raises concerns about fighting off infections or handling medical emergencies.

Missions longer than this would push the limits of human endurance.

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Alicia Witt in Urban Legend

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